Isosorbide: Isosorbide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy. In a human radio-labelled drug study, about 93% of the total dose was excreted in the urine within 48 hours. Expert Opin Drug Metab Toxicol. Eur J Pharm Biopharm. [, Pedretti A, De Luca L, Marconi C, Regazzoni L, Aldini G, Vistoli G: Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. [, Joseph SS, Lynham JA, Colledge WH, Kaumann AJ: Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Vascul Pharmacol. The metabolism of Doxazosin can be decreased when combined with Abiraterone. 1986 Feb;75(2):146-9. doi: 10.1002/jps.2600750208. [, Young RA, Brogden RN: Doxazosin. Drug Metab Rev. [, Hammond KP, Nielsen C, Linnebur SA, Langness JA, Ray G, Maroni P, Kiser JJ: Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report. Pharmacol Rev. Hypertension. Cefuroxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. J Am Acad Dermatol. A comparative review. The metabolism of Sotalol can be decreased when combined with Abiraterone. The absence of an interaction does not necessarily mean no interactions exist. [, Walden RJ, Hernandez R, Witts D, Graham BR, Prichard BN: Effect of food on the absorption of hydralazine in man. 2 This drug is more resistant to the [, Belfort MA, Anthony J, Saade GR, Allen JC Jr: A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. Edinburgh: Elsevier/Churchill Livingstone. Absorption. In contrast to other PDE5 inhibitors Isosorbide mononitrate 2-glucuronide; Route of elimination. ALFASID 1 GR IM ENJ. In Encyclopedic reference of molecular pharmacology (pp. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Doxazosin may cause hypotension due to its pharmacological actions. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. 11 It was developed out of a need for therapies active against isoniazid Easily compare up to 40 drugs with our drug interaction checker. Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. Nimodipine is a 1,4-dihydropyridine calcium channel blocker. 2018 Dec;15(12):1862-1869. doi: 10.1016/j.hrthm.2018.07.010. The serum concentration of Sotalol can be increased when it is combined with Acetophenazine. Nimodipine may increase the arrhythmogenic activities of Adenosine. The risk or severity of adverse effects can be increased when Sotalol is combined with Acetylcholine. The risk of these effects is particularly high when dose adjustments occur or there are long intervals between doxazosin doses. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. 8 The absorption is dose-dependent and increases with higher Isosorbide mononitrate has a dose-linear kinetics and the absolute bioavailability is nearly 100%. 3 Bacitracin was In Comprehensive Hypertension (pp. Pediatrics. [, Roehrborn CG, Schwinn DA: Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. In one cross-section study, intrathecal baclofen was J Biol Chem. Vitamin B12; Vitamin B12 complex; Vitamin B12 NOS; Pharmacology Indication. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. [, Cubeddu LX, Fuenmayor N, Caplan N, Ferry D: Clinical pharmacology of doxazosin in patients with essential hypertension. Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. [, Chien DS, Sandri RB, Tang-Liu DS: Systemic pharmacokinetics of acitretin, etretinate, isotretinoin, and acetylenic retinoids in guinea pigs and obese rats. J Auton Pharmacol. 2002 Jan 1;30(1):412-5. 12 Indicated for use to improve exercise tolerance in patients with chronic stable angina. Arterial relaxation leads to reduced systemic vascular resistance and systolic blood (aortic) pressure, decreasing to decreased cardiac afterload.7,3 The direct dilator effect on coronary arteries opposes the coronary artery spasm in variant angina or angina pectoris.3 At larger doses, nitric oxide causes the resistance arteries and arterioles to dilate, reducing arterial pressure via coronary vasodilatation. Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT 1 receptor subtype. 15 Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment Generic Name Olanzapine DrugBank Accession Number DB00334 Background. Easily compare up to 40 drugs with our drug interaction checker. The metabolism of Abemaciclib can be decreased when combined with Hydralazine. Naunyn Schmiedebergs Arch Pharmacol. The metabolism of Doxazosin can be increased when combined with Abatacept. Biochem J. 2008 Mar;15(3):193-9. doi: 10.1111/j.1442-2042.2007.01956.x. 2007 May;21(5):538-41. doi: 10.1089/end.2006.0107. [, Takara K, Sakaeda T, Kakumoto M, Tanigawara Y, Kobayashi H, Okumura K, Ohnishi N, Yokoyama T: Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport. 1997 Jun;36(6 Pt 2):S96-103. 6 It was the first of the class III anti arrhythmic drugs. This information should not be interpreted without the help of a healthcare provider. Hydroxylated metabolite, Doxazosin; Route of elimination. Acetylsalicylic acid may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. 1999;36 Suppl 1:35-41; discussion 65. J Cardiovasc Electrophysiol. Xi An Lin (Changzhou Pharmaceutical Factory), sulfonamide, secondary alcohol, secondary amino compound, ethanolamines (, Potassium voltage-gated channel subfamily H member 2, C07AA Beta blocking agents, non-selective, C07BA Beta blocking agents, non-selective, and thiazides, C07B BETA BLOCKING AGENTS AND THIAZIDES, C07FX02 Sotalol and acetylsalicylic acid, C07FX Beta blocking agents, other combinations, C07F BETA BLOCKING AGENTS, OTHER COMBINATIONS, Beta Blocking Agents, Non-Selective, and Thiazides, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Heart Failure With Preserved Ejection Fraction (HFpEF), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-ITFT , negative, splash10-0udi-0090000000-b3dca1dbda7d2457ee97, splash10-00di-0090000000-a29ae691c7c3aac0cd25, splash10-00di-0090000000-3826232ebd5c11e1fb09, splash10-0uk9-0590000000-c1cd421f642943a3e40d, splash10-00di-0090000000-62e0058eee644436c974, splash10-00di-0090000000-1c2e1183f392f02dd2f3, splash10-00di-0900000000-467f723fa9c5b11ac3a0, splash10-0udi-0090000000-ec702c0822212cb2e764, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0a4i-0090000000-3fe820b16cdb741dfa3e, splash10-0ab9-0090000000-ba1b9c76db4e9239d8ff, splash10-0a4i-0090000000-9855a87a9a317eccb37e, splash10-03e9-0690000000-0c5b752605586d60828a, splash10-001i-0910000000-399c8ea4647bc5a24781, splash10-001i-0900000000-f44d2d18cd4dfd9b2756, splash10-053r-0900000000-422f178f83cadcda84d7, splash10-0ab9-0090000000-06e3079747baad9d6087, splash10-0a4i-0090000000-69df046b345e5e50d742, splash10-03e9-0690000000-94ba050da9e6a24f29b1, splash10-001i-0910000000-0ef0a4777ff5e99c8462, splash10-001i-0900000000-52c0f117b0c8ef4e0b76, splash10-053r-0900000000-ade6b1782a916acc1d7e, splash10-0a4i-0090000000-ef1bcb821ca9cd1627a8, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-0a4i-0090000000-75d846e48f9d41af615c, splash10-03e9-0790000000-610bf5222b1cb6f67b93, splash10-053r-0900000000-943fd2d5d938aa51d8d5, splash10-001i-0920000000-7400cd81d8ca70325a62, splash10-053r-0900000000-3b49e7b47aa69566cb3a, splash10-0a4i-0090000000-36ad35b8c37f5c9f4e91, splash10-0a4i-0090000000-1f8f59e1c29a48907b1d, splash10-0a4i-0390000000-7e44e05711b4dc722309. Depending on the formulation administered, prescribing information for orally administered delayed-released tablets of 2.4g or 4.8g of mesalazine given once daily for 14 days to healthy volunteers was to found to be about 21% to 22% of the administered dose Label while prescribing information for an orally administered controlled-release capsule formulation Acetaminophen may decrease the excretion rate of Ampicillin which could result in a higher serum level. [. 2006 Dec;5(12):1029-32. Oncol Res. 1987 Apr;41(4):439-49. doi: 10.1038/clpt.1987.54. 2006 Jul 1;574(Pt 1):149-66. Dimethyl sulfoxide: Dimethyl sulfoxide may decrease the excretion rate of Dextran which could result in a higher serum level. J Chromatogr. J Invest Dermatol. 2003 Oct-Dec;23(5-6):275-83. Avoid life-threatening adverse drug events & improve clinical decision support. Acetazolamide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy. Pharmacodynamics. [, Zhao XJ, Ishizaki T: Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. Generic Name Acetaminophen DrugBank Accession Number DB00316 Background. Label The maximum plasma concentration is 3.1-5.3ng/mL for a 0.4mg oral dose and 2.5-3.6ng/mL for a 0.8mg oral dose. [, Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. 1981 Nov-Dec;9(6):515-20. Aceclofenac may decrease the antihypertensive activities of Hydralazine. Generic Name Sotalol DrugBank Accession Number DB00489 Background. Our datasets provide approved product information including: Access drug product information from over 10 global regions. Pharmacology Indication. Doxazosin is an alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.4,7 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Generic Name Bacitracin DrugBank Accession Number DB00626 Background. The metabolism of Acalabrutinib can be decreased when combined with Doxazosin. Food increases exposure to hydralazine, though this may not be clinically significant. Oral tamsulosin is 90% absorbed in fasted patients. Acetylsalicylic acid may decrease the antihypertensive activities of Nimodipine. Dinoprostone: The excretion of Dinoprostone can be decreased when combined with Cefotaxime. Baclofen is an antispasmodic agent that induces muscle relaxation. 11 Intravenous Hum Exp Toxicol. Aceclofenac may decrease the antihypertensive activities of Sotalol. 1983 Mar 17;308(11):619-24. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Vitamin B12; Vitamin B12 complex; Vitamin B12 NOS; Pharmacology Indication. [, Layton A: The use of isotretinoin in acne. The absorption is unaffected by food. Drug Intell Clin Pharm. [, FDA Approved Drug Products: Betapace (sotalol) tablets for oral use [, FDA Approved Drug Products: Sotalol hydrochloride for intravenous injection [, FDA Approved Drug Products: Sotylize (sotalol hydrochloride) solution for oral use [, Murfreesboro Pharmaceutical Nursing Supply, Lowe MD, Lynham JA, Grace AA, Kaumann AJ: Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. This information should not be interpreted without the help of a healthcare provider. Cefuroxime may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. 2000 Aug;21(8):690-4. Oral tamsulosin is 90% absorbed in fasted patients. [, Dietz JD, Du S, Bolten CW, Payne MA, Xia C, Blinn JR, Funder JW, Hu X: A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. [, Vane FM, Bugge CJ: Identification of 4-oxo-13-cis-retinoic acid as the major metabolite of 13-cis-retinoic acid in human blood. 1997 Jul;282(1):228-35. 11 The peak response of amphetamine occurs 1-3 hours after oral administration and approximately 15 minutes after 1988 May;35(5):525-41. doi: 10.2165/00003495-198835050-00003. Epub 2007 Feb 27. Download (73.3 KB) Clinical Trials Clinical Trials . Indian J Anaesth. Ampicillin may decrease the excretion rate of Acrivastine which could result in a higher serum level. The risk or severity of hypoglycemia can be increased when Sotalol is combined with Acetohexamide. Take with or without food. If you believe you are experiencing an interaction, contact a healthcare provider immediately. This information should not be interpreted without the help of a healthcare provider. Drug created at June 13, 2005 13:24 / Updated at November 08, 2022 04:59. Generic Name Nitrofurantoin DrugBank Accession Number DB00698 Background. 2009 Feb;65(2):218-25. doi: 10.1002/ana.21542. Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. 1996 Jul 26;52(2):187-95. Munzel T, Steven S, Daiber A: Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction. 2009;17(11-12):527-33. [, Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Am Heart J. Label The maximum plasma concentration is 3.1-5.3ng/mL for a 0.4mg oral dose and 2.5-3.6ng/mL for a 0.8mg oral dose. U.S. Patent US3978078, issued December, 1974. Epub 2010 Jan 20. 2006 Nov;152(5):842-50. The extended-release forms of the drug are also available generically and under the brand name Imdur.7, Isosorbide mononitrate is indicated for the prevention and management of angina pectoris due to coronary artery disease. N Engl J Med. 1981 Aug;24(8):987-93. doi: 10.1002/art.1780240802. Card Electrophysiol Clin. J Pharm Pharmacol. Clin Infect Dis. A.. Expert Rev Cardiovasc Ther. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. [, FDA Approved Drug Products: Accutane Oral Capsule [, Health Canada Product Monograph: Accutane Roche (isotretinoin) capsules for oral administration [. Oral sotalol with a meal reduces absorption by 20%. Discover Part 6 of the Quality Data series: D10AD Retinoids for topical use in acne, D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE, D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE, Drugs causing inadvertant photosensitivity, MS/MS Spectrum - Quattro_QQQ 10V, Positive, splash10-0udi-0009000000-12dbd83959268dee6dbf, MS/MS Spectrum - Quattro_QQQ 25V, Positive, splash10-066r-4900000000-31c9262cbbf0bad5b738, MS/MS Spectrum - Quattro_QQQ 40V, Positive, splash10-0fsl-9600000000-c6681587f0a9ae7a712e, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated). This information should not be interpreted without the help of a healthcare provider. Aceclofenac may decrease the excretion rate of Ampicillin which could result in a higher serum level. Acemetacin may decrease the antihypertensive activities of Hydralazine. Am J Cardiol. Depending on the formulation administered, prescribing information for orally administered delayed-released tablets of 2.4g or 4.8g of mesalazine given once daily for 14 days to healthy volunteers was to found to be about 21% to 22% of the administered dose Label while prescribing information for an orally administered controlled-release capsule formulation Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. The metabolism of Acalabrutinib can be decreased when combined with Hydralazine. 8 In a strict sense, A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. [, Hendrix CW, Jackson KA, Whitmore E, Guidos A, Kretzer R, Liss CM, Shah LP, Khoo KC, McLane J, Trapnell CB: The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Epub 2016 Sep 2. Drug Metab Dispos. Epub 2006 May 4. Rev Urol. Isosorbide mononitrate may decrease the excretion rate of Aclidinium which could result in a higher serum level. Alcohol with isotretinoin can lead to inflammation of the liver. Patients must be advised of the priapism risk associated with doxazosin and to seek medical attention immediately if it is suspected.9,19, Doxazosin selectively inhibits the postsynaptic alpha-1 receptors on vascular smooth muscle by nonselectively blocking the alpha-1a, alpha-1b, and alpha-1d subtypes12,13. Antimicrob Agents Chemother. J Craniofac Genet Dev Biol. 2002 Jan 1;30(1):412-5. Clin Pharmacokinet. Life Sci. 4 The oral bioavailability of furosemide from oral tablets or oral solution is about 64% and 60%, respectively, of that from an intravenous injection of the drug. Pharmacotherapy. Auton Autacoid Pharmacol. 2000 Jan 21;275(3):1699-707. http://www.chemspider.com/Chemical-Structure.5063.html, 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The patient's legs should be passively elevated, and intravenous infusion of normal saline or similar fluid is recommended. 2000 Nov 24;87(11):1012-8. doi: 10.1038/cddis.2011.77. Dimethyl sulfoxide: Cefotaxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. Drug Metab Dispos. J Pharm Sci. 1982 Aug-Sep;22(8-9):395-402. This information should not be interpreted without the help of a healthcare provider. [, Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. 1987 May 29;59(14):78G-81G. Download (73.6 KB) Clinical Trials Clinical Trials . Amphetamine is well absorbed in the gut and as it is a weak base hence the more basic the environment the more of the drug is found in a lipid-soluble form and the absorption through lipid-rich cell membranes is highly favored. 1999 Apr;289(1):448-54. The use of epinephrine or other arterial vasoconstrictors is not recommended.4, Drug created at June 13, 2005 13:24 / Updated at November 08, 2022 04:59. Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . The first dose of doxazosin may lead to such effects, however, subsequent doses may also cause them. Isosorbide: Isosorbide may increase the excretion rate of Nitroprusside which could result in a lower serum level and potentially a reduction in efficacy. 8,9,10 Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. Build, train, & validate predictive machine-learning models with structured datasets. Epub 2007 Jan 16. [, Shannon R, Chaudhry M: Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Following oral administration, it is rapidly absorbed through the gastrointestinal tract with peak plasma concentrations being reached two to three hours after ingestion. Avoid alcohol. Treatment should be started with the 1 mg dose of doxazosin, followed by slow titration to the appropriate dose.19 Patients must be advised of this risk and to avoid situations in which syncope and dizziness could be hazardous following the ingestion of doxazosin.19 Interestingly doxazosin exerts beneficial effects on plasma lipids. The majority of hydralazine clearance is extrahepatic- 55% for rapid acetylators and 70% for slow acetylators.9 The average clearance in congestive heart failure patients is 1.770.48L/kg/h,9 while hypertensive patients have an average clearance of 42.78.9mL/min/kg.14, The oral LD50 in rats is 173-187mg/kg and the highest known dose an adult human has survived is 10g orally.19, Patients experiencing an overdose may present with hypotension, tachycardia, headache, flushing, myocardial ischemia, myocardial infarction, cardiac arrhythmia, and shock.19 Overdose can be treated through emptying the gastric contents and administering activated charcoal, though these treatments may cause further arrhythmias and shock.19 Supportive and symptomatic treatment should be administered.19, Drug created at May 16, 2007 20:38 / Updated at November 08, 2022 04:59. Approximately 70% of absorbed methyldopa is excreted in the urine as unchanged parent drug (24%) and -methyldopa mono-O-sulfate (64%), 6,11 with variability.3-O-methyl--methyldopa accounted for about 4% of urinary excretion products. U.S. Patent US20080207946, issued August 28, 2008. 2005;7 Suppl 8:S34-42. Discover Part 6 of the Quality Data series: Cardenalin (Pfizer (Japan; discontinued)), Carduran (Pfizer (Brazil, Denmark, Norway, Spain)), N-arylpiperazine, monocarboxylic acid amide, aromatic amine, quinazolines, benzodioxine, N-acylpiperazine (, C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING, Antiadrenergic Agents, Peripherally Acting, Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 CYP3A4 Substrates (strength unknown), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QFT , negative, splash10-0udi-0010900000-9601aa919c95799ec009, splash10-0kei-0981100000-a9ee3121ba6832366f8e, splash10-0a4i-0970000000-5261f1bc60ceee4364de, splash10-0a4i-0950000000-f649236044e4e2a5de38, splash10-0a4i-1920000000-86655cc3bb892d757068, splash10-0a4i-1900000000-88bca2ddf2930fa0c468, LC-MS/MS Spectrum - LC-ESI-QFT , positive, splash10-0udi-0000900000-449254642300c1324285, splash10-0udi-0002900000-3097c8a3403b52610918, splash10-0006-0079100000-06d36a9b7afe6cf0c6e9, splash10-000t-1091000000-cbd9b2106818ef5fd2ba, splash10-001i-1190000000-a1c84b0c3657d8000e35, splash10-001i-1390000000-e802cb93ca8d6934ee96, HERG human cardiac K+ channel (Protein Group), Potassium voltage-gated channel subfamily H member 2, Potassium voltage-gated channel subfamily H member 6, Potassium voltage-gated channel subfamily H member 7. Sotalol is a methanesulfonanilide developed in 1960. 2005 Nov;96(7):1131-5. 1989 Oct;78(10):867-73. doi: 10.1002/jps.2600781018. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood brain barrier. 1992 Mar-Apr;20(2):211-7. 2007 Feb 12;96(3):424-31. doi: 10.1038/sj.bjc.6603554. [, Tsukada M, Schroder M, Seltmann H, Orfanos CE, Zouboulis CC: High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intracellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes. Eur J Clin Pharmacol. This information should not be interpreted without the help of a healthcare provider. [, Choi JS, Burm JP: Enhanced nimodipine bioavailability after oral administration of nimodipine with morin, a flavonoid, in rabbits. [, Juberg EN, Minneman KP, Abel PW: Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart. [, Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. [, Vergouwen MD, Vermeulen M, Roos YB: Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review. Sotalol is a methanesulfonanilide developed in 1960.6 It was the first of the class III anti arrhythmic drugs.6 Sotalol was first approved as an oral tablet on 30 October 1992.8 A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.Label,9,10, Sotalol is indicated to treat life threatening ventricular arrhytmias and maintain normal sinus rhythm in patients with atrial fibrillation or flutter.Label There are also oral solutions and intravenous injections indicated for patients requiring sotalol, but for whom a tablet would not be appropriate.Label,9,10, Sotalol is a competitive inhibitor of the rapid potassium channel.2 This inhibition lengthens the duration of action potentials and the refractory period in the atria and ventricles.3,4 The inhibition of rapid potassium channels is increases as heart rate decreases, which is why adverse effects like torsades de points is more likely to be seen at lower heart rates.6 L-sotalol also has beta adrenergic receptor blocking activity seen above plasma concentrations of 800ng/L.6 The beta blocking ability of sotalol further prolongs action potentials.6 D-sotalol does not have beta blocking activity but also reduces a patient's heart rate while standing or exercising.6 These actions combine to produce a negative inotropic effect that reduces the strength of contractility of muscle cells in the heart.2 Extension of the QT interval is also adversely associated with the induction of arrhythmia in patients.4, Hyperglycemia is a greater risk for non insulin dependant diabetics than insulin dependant diabetics.7 Beta blockers inhibit insulin secretion which may cause hyperglycemia in type II diabetes mellitus.7 The risk of hypoglycemia is higher in insulin dependant diabetes than non insulin dependant diabetics.7 Beta blockers decrease secretion of insulin, which may mask hypoglycemia in an insulin dependant patient.7 Beta blockers also increase glucose uptake into cells which may prolong or potentiate hypoglycemia.7, Further information regarding adverse reactions can be found here.11, Sotalol inhibits beta-1 adrenoceptors in the myocardium as well as rapid potassium channels to slow repolarization, lengthen the QT interval, and slow and shorten conduction of action potentials through the atria.2,3,4,5 The action of sotalol on beta adrenergic receptors lengthens the sinus node cycle, conduction time through the atrioventricular node, refractory period, and duration of action potentials.6, Sotalol is 90-100% bioavailable.Label,1 When taken with a meal, adsorption is lowered by 18%.Label,1 Crit Care. The metabolism of Acenocoumarol can be decreased when combined with Doxazosin. BJU Int. Pharmaceutical Utilization Management Program VA Inc. Dahl AR, Grossi IM, Houchens DP, Scovell LJ, Placke ME, Imondi AR, Stoner GD, De Luca LM, Wang D, Mulshine JL: Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Int J Pharm. Improve clinical decision support with information on. 6 It was the first of the class III anti arrhythmic drugs. Pharmaceutical Utilization Management Program VA Inc. Yono M, Foster HE Jr, Shin D, Takahashi W, Pouresmail M, Latifpour J: Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract. Ampicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level. Take with or without food. High-fat food increases drug absorption. The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Acarbose. Pharmacology Indication. Oct ; 78 ( 10 ):867-73. doi: 10.1038/sj.bjc.6603554 with Abatacept:439-49. doi: 10.1038/sj.bjc.6603554 & Improve decision... With Abiraterone 1983 Mar 17 ; 308 ( 11 ):619-24 1983 Mar ;.:424-31. doi: 10.1038/sj.bjc.6603554 one cross-section study, about 93 % of total... R, Chaudhry M: Effect of Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign hyperplasia! Angiotensin II antagonist that acts on the at dimethyl isosorbide msds receptor subtype with chronic stable angina structured datasets KB! 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