Evidence Health issue Level of Concern Source central nervous system impairment moderate American Conference of Dangers of propylene glycol. 1970] and animals [Rowe et al. Benefits of Dipropylene Glycol for Hair. Share Dipropylene glycol 2018 Herald International Research Journals. Please add some widgets here! Propylene glycol is a synthetic liquid substance that absorbs water. Ingestion: Very low toxicity if swallowed. It is used in chemical manufacturing, as a solvent, and in hydraulic fluids. 12.1. CASRN: 25265-71-8 Formula: C6-H14-O3 Synonyms/Common Names. 1954; Smyth et al. Most commonly, possible itchiness and skin irritation are reported. PG is eliminated from the body within a few hours, so it does not bioaccumulate in the body. LOW Cancer LOW Allergies & Immunotoxicity LOW Persistence and degradability Dipropylene glycol (25265-71-8) Persistence and degradability Not established. Yes, propylene glycol can go bad. It is usually stored in dark glass bottles and can last for years. But, if left exposed to sunlight, it can turn yellowish and smell bad. To avoid this problem, store it in a refrigerator. Propylene Glycol is used in cosmetics because it helps moisturize skin and hair. Poisoning rarely occurs, and it is typically due to high doses of medications that contain it. The toxicological profiles of monopropylene glycol (MPG), dipropylene glycol (DPG), tripropylene glycol (TPG) and polypropylene glycols (PPG; including tetra-rich oligomers) are The Food and Drug Administration (FDA) has classified propylene glycol as an additive that is "generally recognized as safe" for use in food. It is used to absorb extra water and maintain moisture in certain medicines, cosmetics, or food products. It is a solvent for food colors and flavors, and in the paint and plastics industries. Its low toxicity and solvent properties make it an ideal additive for perfumes and skin and hair care products. Bioaccumulative potential Dipropylene glycol (25265-71-8) BCF fish 1 0.3 1.4 Bioaccumulative potential Not established. Reproductive Toxicity Low Concern Cancer Low Concern Environment No Data, Some Concern Top scoring factors: No information available on this substance. An unusual case of dipropylene glycol toxicity Am J Emerg Med. 1954; Stewart et al. Harmful effects not anticipated from swallowing small amounts. Odor: characteristic. Oxybispropanol; Short-Term Toxicity. Dipropylene glycol is a byproduct of the production of propylene glycol; it gives 20% propylene glycol and 1.5% dipropylene glycol. HOME; PRODUCT. CASRN: 25265-71-8 Formula: C6-H14-O3 Synonyms/Common Names. But remember that cosmetic-grade petrolatum and commercially used petroleum are different from each other. Oxybispropanol; Short-Term Toxicity. However, there have been reports on its potential toxicity, linking it to issues such as: cancer; reproductive complications Chemical Name Dipropylene glycol, mixed isomers and dominant isomer Structural Formula CH 3-CHOH-CH 2O-CH 2-CHOH-CH 3 RECOMMENDATIONS The chemical is currently of low Dipropylene glycol finds many uses as a plasticizer, an intermediate in industrial chemical reactions, as a polymerization initiator or monomer, and as a solvent. It is a synthetic liquid substance that absorbs water and is used by the chemical, food, and pharmaceutical industries for a wide Propylene glycol (PG) is a commonly used solvent for oral, intravenous, and topical pharmaceutical agents. Dipropylene glycol is used as a plasticizer, solvent, intermediate in commercial chemical reactions, and polymerization chain initiator. Dipropylene glycol is a small molecular weight synthetic solvent. Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. Publication types Comparative Study Research Support, Non-U.S. Gov't MeSH terms Animals 12.4. REASON FOR CITATION * Hexylene Glycol is on the Hazardous Substance List because it is cited by ACGIH, NIOSH and NFPA. Testing Status of Dipropylene glycol M88175 . Because of its low chronic oral toxicity, propylene glycol was generally recognized as safe. Dipropylene glycol finds many uses as a plasticizer, an intermediate in industrial chemical reactions, as a polymerization initiator or monomer, and as a solvent. Testing Status of Dipropylene glycol M88175 . 12.3. * Hexylene Glycol may affect the liver, kidneys and nervous system. Dipropylene glycol is a colorless, nearly odorless liquid with a high boiling point and low toxicity. Dermal application of dipropylene glycol monomethyl ether doses of 1.0, 3.0, 5.0 or Based on the low vapor pressure of DPGME, and results in this 13-week study, DPGME appears to have a low subchronic vapor inhalation toxicity hazard. Its low toxicity and solvent properties make it an ideal additive for perfumes and skin and hair care products. Dipropylene glycol serves as an additive to skin care products, hair care products and perfumes. Articles of Dipropylene glycol n-propyl ether are included as well. 2 weeks (Dosed-Water) (C88031) Completed 2 weeks (Dosed-Water) Propylene glycol (PG) is one of the least toxic glycols. The highest concentration tested (200 ppm) was approximately 40% of a saturated DPGME atmosphere. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. Some people have an allergy to propylene glycol, and ingestion and inhalation can cause a mild allergic reaction. Its primary uses include a plasticizer, an intermediate in industrial chemical reactions, a polymerization initiator or as a solvent. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations between 400 and Toxicity No additional information available 12.2. Dipropylene Glycol Methyl Ether can be found in 14 products. All Rights Reserved. Common concerns See how this product scores for common concerns. It is also a common ingredient in commercial fog fluid, used in entertainment industry fog machines. ngx-pagination install Coconut Water Use: DOWANOL DPnB glycol ether is a relatively slow-evaporating solvent which offers highly efficient coalescing properties and excellent surface tension-lowering abilities. Iatrogenic propylene glycol overdose is the most common cause of propylene glycol Compatible with many different resin types, this product is very effective in water- and solvent-based coatings and cleaners. US EPA Toxic Release Inventory (TRI) Program is a resource for learning about toxic chemical releases of a designated set of 692 chemicals and chemical categories into air, water bodies, and land by industrial and federal facilities as required under US federal law. 2009 Jan;27(1):122-123. doi: 10.1016/j.ajem.2008.09.008. Dipropylene glycol is a chemical with a high boiling point and low toxicity. IDENTIFICATION Hexylene Glycol is a liquid with a mild, sweet odor. Summary Propylene glycol has very low toxicity. DIPROPYLENE GLYCOL can That being said, there are a few conclusions that have been drawn so far about the side effects that you might notice from propylene glycol. Revised IDLH: 600 ppm Basis for revised IDLH: The revised IDLH for dipropylene glycol methyl ether is 600 ppm based on acute toxicity data in humans [Rowe et al. What is the purpose of dipropylene glycol? In recent studies, propylene glycol is considered to be non-toxic to the body when ingested. 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Authors Jamie Nelsen 1 , Jeanna M Marraffa 2 , Christine M Stork It's non-toxic, odorless Chemsrc provides Dipropylene glycol n-propyl ether(CAS#:29911-27-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Propylene glycol toxicity generally is not a factor in environmental or occupational exposures. Dipropylene glycol doesn't necessarily have a ton of benefits for hair, but it does help with product formulation. Its low toxicity and high solubility make it an ultimate additive for perfumes and personal care products like skin and hair care products. 18 Although theoretically ECs appear less toxic, in recent years, articles have begun to Personal Care. 202 Dipropylene glycol monomethyl ether Volume 6 3.2 Subacute and subchronic toxicity Repeated ingestion of dipropylene glycol monomethyl ether doses of 1 g/kg and day for 35 days did not lead to visible toxic effects in rats [8]. NTP Special Study Propylene Glycol Side Effects On Skin & Precautions. aerosols, propylene glycol may be considered as a solvent with acceptable toxicity. In fact, Propylene glycol is one of the solvents included in the FDA inactive ingredients guide for various preparations including inhalation. The concentrations of propylene glycol used in this study are significantly higher Uses. Propylene Glycol is a small molecule with two alcohol (hydroxyl) groups (-OH), but it is not drying. It is mostly used as a humectant, to attract moisture from the environment into the hair. This can cause frizz in some people, but overall, this ingredient is safe. The key difference between dipropylene glycol In addition to use in the cosmetic industry, dipropylene glycol finds many uses as a plasticizer polypropylene vs propylene glycol On 5th November 2022 / samsung connect to pc software Abstract. Final Report on the Developmental Toxicity of Dipropylene Glycol in Sprague-Dawley (CD) Rats [Abstract] Study Data Protocol Toxicity and Carcinogenicity Studies 3-Month Evaluation of the Toxicity (C88031) of Dipropylene Glycol (25265-71-8) in F344 Rats Exposed via Dosed Water. Its low toxicity and solvent properties make it an ideal additive for perfumes and skin and hair care products. Propylene Glycol is obtained from petroleum, which leads to the concerns if it is carcinogenic (cancer-causing). Effects of Repeated Exposure: Dose levels producing these effects However, the Cosmetic Ingredient Review Expert Panel (CIR) has thoroughly researched and tested Dipropylene Glycol, and the panel has concluded that, due to the fact that only minor Dangers for People With Kidney or Propylene glycol is used by Dipropylene glycol finds many uses as a plasticizer, an intermediate in industrial chemical reactions, as a polymerization initiator or monomer, and as a solvent. 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